New DNA ‘shredder’ technique goes beyond CRISPR’s scissors – A Spiritual Insight

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“CRISPR” is shorthand notation for “CRISPR-Cas9.” The idea behind CRISPRs are specialized stretches of DNA where the protein Cas9 (or “CRISPR-associated”) is an enzyme that acts like a pair of molecular scissors, capable of cutting strands of DNA. In the last 6 years there has been a lot of press on the genetic editing tool called CRISPR-Cas9. This new tool has transformed genetic research allowing scientists to edit and cut DNA strands at precise locations like one would do with a pair of scissors in the macro world. University of Michigan and Cornell have filed for a joint patent on this new tool called CRISPR-Cas3 to work as long-range DNA editing tool in human cells for the first time. The research was funded by the National Institutes of Health (GM128637, GM118174, GM102543 and GM117268) and by Zhang’s funding from the Medical School’s Biological Sciences Scholars Program. This new tool provides a way to target and delete much longer expanses of DNA than the current Cas9 tool is capable of. This new tool will be used to work in genetic research to understand the underpinnings of disease, and potentially in the treatment for diseases that are associated to long stretches of DNA. The researchers state the following:

The new tool uses a Type I CRISPR, which is much more common in bacteria than the Type II variety that includes Cas9. Type I CRISPR has never been used in any eukaryotic cells, and employs a riboprotein complex known as Cascade for seeking its target and an enzyme called Cas3 for shredding DNA.

The idea behind using this new editing technique is when scientists are studying what they call the “non-coding” long stretches of DNA that don’t contain the code for a particular protein; the “shredder” technique could allow them to demolish a sequence of long stretches and see what happens. The “see what happens” is the result of our knowledge of the human genome still remaining small. Challenges with this type of research is to figure out what stretches of DNA have actually been deleted in order to validate the accuracy of the editing technique. Chinese researchers have reported attempting to use CRISPR-Cas9-based therapeutics for editing out a receptor gene that enables HIV to enter cells in the embryos of babies reportedly born in China. Researchers worries concering CRISPR-Cas9 making unintended edits in the normal areas of human patients’ DNA have also been of concern. Further work will be needed to see if the “shredder” approach avoids this issue.

The Spiritual insights that we receive from this work is related to the DNA editing technique. This is connected to the editing technique that many people do in their bibles, considering certain portions of Scripture as irrelevant in relation to others due to presuppositions that have been developed through modern theologies. There are three places in the Bible that describe this idea of adding or taking away from God’s Word.

Devarim / Deuteronomy 4:2 You shall not add to the word which I am commanding you, nor take away from it, that you may keep the commandments of the Lord your God which I command you. (NASB, ב לֹא תֹסִפוּ עַל-הַדָּבָר אֲשֶׁר אָנֹכִי מְצַוֶּה אֶתְכֶם וְלֹא תִגְרְעוּ מִמֶּנּוּ לִשְׁמֹר אֶת-מִצְוֹת יְהֹוָה אֱלֹהֵיכֶם אֲשֶׁר אָנֹכִי מְצַוֶּה אֶתְכֶם)

Devarim / Deuteronomy 12:32 Whatever I command you, be careful to observe it; you shall not add to it nor take away from it. (NASB, א אֵת כָּל-הַדָּבָר אֲשֶׁר אָנֹכִי מְצַוֶּה אֶתְכֶם אֹתוֹ תִשְׁמְרוּ לַעֲשֹוֹת לֹא-תֹסֵף עָלָיו וְלֹא תִגְרַע מִמֶּנּוּ:)

Revelation 22:18 I testify to everyone who hears the words of the prophecy of this book: if anyone adds to them, God will add to him the plagues which are written in this book; (NASB, מעיד אני בכל השמע דברי נבואת הספר הזה אם יוסיף איש עליהם יוסיף עליו האלהים את המכות הכתובות בספר הזה׃)

These passages are important because they establish a very important principle as the Children of Israel prepared to enter into the Promised Land “Do not add to or take away from the word of God.” The God of Israel, by the hand of Moshe, made this a fundamental principle for the nation as they entered into this new land that He had provided. The foundation of the Word of God is based upon what this nation was to rely upon, the promises of God, His Word, His power, His dwelling in their midst, as they entered into the land that was filled with false gods and false religions. They are being charged to keep the way of God and not modify it per what they considered was right in their own eyes. This was such a significant charge in the Torah that John wrote the following:

Revelation 22:18-19
For I testify to everyone who hears the words of the prophecy of this book: If anyone adds to these things, God will add to him the plagues that are written in this book; and if anyone takes away from the words of the book of this prophecy, God shall take away his part from the Book of Life, from the holy city, and from the things which are written in this book. (NASB)

Adding to or taking away will lead to falling out of fellowship with God. What do we see happening today in the modern theologies that are being developed which marginalizes the Torah? We do not see the power of God moving as we once did, and the reason is based upon what we are reading here in the Torah and in the book of Reelation. Sforno states the following concerning the verse from Devarim / Deuteronomy 13:1 (Note, this verse in the English translations is Devarim / Deuteronomy 12:32).

Sforno on Devarim / Deuteronomy 13:1 Part 1
לא תוסף עליו, for you might add something which is despicable in the eyes of the Lord. If, perchance, you would add new ways of serving the Lord, you have no assurance that such innovation is acceptable to G’d, for instance the burning of one’s children in G’d’s honour.

Sforno on Devarim / Deuteronomy 13:1 Part 2
ולא תגרע ממנו, even if, in your judgment, the rationale for observing the commandment in question no longer applies, is no longer relevant. An example would be Solomon’s reasoning that the restrictions placed by the Torah on the number of wives a king may have did not apply to him as none of these wives could possibly incite him to turn away from G’d. (compare Sanhedrin 21).

Sforno writes concerning adding to the Word of God that by doing so what was added will not be acceptable for God. He uses the extreme example of burning one’s children to Molech, a false god of the Sidonians. He also writes about taking away from the Word of God and makes the comparison to the one who considered a particular scripture no longer relevant. Sforno references the Talmud Bavli Sanhedrin 21a and the rabbinic discussion on taking many wives which leads to one turning from the way of God, and the major theme is to what happened to Solomon, a man blessed with great wisdom and yet being deceived due to his political alliances through marriage. This demonstrates how he trusted in the flesh as opposed to trusting in the Lord God of Israel to protect the nation. What is interesting is how this statement was written so long ago and yet is so relevant for us today. Take for example in the nondenominational churches, the dispensationalists “law vs grace” arguments that are made at the pulpit. The challenge for us today is how we live in a culture that does not consider any part of God’s word as relevant and then those who call upon the Lord develop doctrines and theologies to minimize or marginalize the Torah. By doing so, one is seemingly adding to and taking away from God’s Word. The Lord God has told us that we will one day have to give an account of our lives before Him, but many Bible teachers seem to want to leave that part of the message out for fear of offending followers. How much better it would be if they would communicate the life-changing truths that God has given us! The Torah is a text that was written by the hand of Moshe who spoke to God face to face. No other man in all of history ever spoke to God face to face. It can be said with certainty, the Torah is the word of God that was dictated directly from the mouth of God Himself. This is why the Torah is the foundation stone of all of Scripture. God has given us the exact, precise message that we need for life. Because of this, it is impressed upon us to know and to heed every word of the Bible! The Rambam wrote saying, “Everyone who trusts has faith, but not everyone who has faith trusts.” This is a significant point because one may say they have faith or that they believe God’s Word, but it is only when faith is put into practice (faithfulness) that one’s faith becomes evident. When we delight in the Lord by seeking to make His will our highest priority, then our requests will be fulfilled. This is what Yeshua was teaching us when he said If you remain in me, and my words remain in you, ask whatever you wish, and it will be done for you.” (John 15:7) The essential command that we are given is to “trust in the Lord with all your heart; and lean not unto thine own understanding. In all thy ways acknowledge him, and he shall direct thy paths.” (Mishley / Proverbs 3:5-6, ה בְּטַח אֶל-יְהֹוָה בְּכָל-לִבֶּךָ וְאֶל-בִּינָתְךָ אַל-תִּשָּׁעֵן: ו בְּכָל-דְּרָכֶיךָ דָעֵהוּ וְהוּא יְיַשֵּׁר אֹרְחֹתֶיךָ:) Trusting in God involves translating faith into the realm of action. In every aspect of human life, religious, moral, social, civil, environmental, agricultural, dietary, sexual, and so on, the Torah has a voice on the matter. In the scope of the commandments of God, there is no dividing line between the sacred and the profane in the life of the tzaddik (the righteous). The various commands given to us in the Torah were given because the spiritual realm was intended to permeate every aspect of our lives (1 Corinthians 10:31). The Torah helps us to be mindful of these things, and walking in the ways of the Messiah Yeshua, the Torah commands helps to “wake up” the divine presence in our lives regarding every practical decision that we make. This teaches us how the Scriptures, the Word of God, is intended to awaken us to the reality of God’s immanent presence, He is here, now, and tangible in our lives. When Yeshua was here on earth, he studied the Torah, read the Torah, and clearly taught us to keep the ways of the Lord (Luke 4:16, Matthew 7:12). The point is by the power of God we are no longer enslaved to the power of sin but have a new principle that leads to true freedom, being able to walk in God’s ways by the indwelling of His Spirit. This transforming power of God in the Messiah Yeshua is the Gospel Message that we are being taught in the Torah, and in all of Scripture.

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Duane D. Miller received his Ph.D., M.S., and B.S. Degree in Chemical Engineering from The University of Akron Ohio. He is currently a Chemical Engineering Researcher. Duane’s research expertise has focused upon functional materials development for the control, conversion, and release of process gases in Energy production technologies. His R&D interests include computational chemistry, developing novel technologies for converting biomass to fuels and studying their fundamental interactions during the chemical conversion process. His past experience includes sorbent development for pre- and post-combustion CO2 and SO2 capture, selective absorption of H2S from methane streams, O2 capture for oxy-fuel combustion, photocatalytic reduction of alcohols, NOx reduction catalysis, the development of oxygen carriers to combust fossil fuels (CH4 and coal) for the chemical looping combustion processes, and the extraction of rare earth elements using patent pending sorbents. His research expertise has focused on operando-characterization using Infrared, Raman, and UV-Vis spectroscopy to observe the nature of the catalytic active sites and reaction intermediates under realistic reaction conditions, allowing direct correlation of molecular/electronic structures with catalyst performance during Gas-Solid / Liquid-Solid Adsorption and Photocatalytic Processes with real time online analysis of reaction products using ICP-MS and mass spectrometry. His current work involves a multi-disciplinary approach to developing, understanding, and improving the catalytic gasification of coal and methane, high temperature chemical looping combustion, and the catalytic decomposition and gasification of biomass and coal using novel microwave reactor.​ He has been studying the Hebrew Scriptures and the Torah for 20+ years and sharing what he has learned. The studies developed for MATSATI.COM are freely to be used by everyone, to God be the Glory!