How does DNA know which job to do in each cell? – A Spiritual Insight

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We have all heard it said that every cell in our bodies contains the blueprint for who we are physically. When performing a search on the number of cells in the human body, the search results state on average we have 30 to 40 trillion cells. There are 11 types of Cells in the Human Body, stem cells, bone cells, blood cells, muscle cells, fat cells, skin cells, nerve cells, endothelial cells, sex cells, pancreatic cells, and cancer cells. The question is how do our cells know what to do with DNA? What determines which genes are switched on when in a blood cell or an olfactory cell for example? How does the cell know to carry out its specific function? These are all very good questions!

References

  1. Venkataramana Kandi and Sabitha Vadakedath, “Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review,” Cureus 2015 Aug; 7(8): e309. DOI: 10.7759/cureus.309, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582005/

On a cellular basis, DNA coding is a highly regulated process. The DNA serves as an instruction manual which provides instructions to mRNA (messenger RNA) which is used for protein production. The transcription of the correct piece of DNA into the mRNA for protein production is the first step to ensuring the cell has the protein it needs for its proper function. There is a protein called “transcription factor” that turns on and off genes. The transcription factor (TF) binds to the DNA in order to increase or decrease the expression of specific genes. The next question is where does the transcription factor come from? Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as the regulome. (Regulome refers to the whole set of regulatory components in a cell.) TFs are of interest in medicine because TF mutations can cause specific diseases, and medications can be potentially targeted toward them. Transcription factors (like all proteins) are transcribed from a gene on a chromosome into RNA, and then the RNA is translated into protein. Any of these steps can be regulated to affect the production (and thus activity) of a transcription factor. An implication of this is that transcription factors can regulate themselves. For example, in a negative feedback loop, the transcription factor acts as its own repressor: If the transcription factor protein binds the DNA of its own gene, it down-regulates the production of more of itself. This is one mechanism to maintain low levels of a transcription factor in a cell. In a cell nucleus, the DNA, proteins, and RNA all work together to repackage the long strands of DNA. This trio is called chromatin. The DNA is wrapped around a complex of proteins which are called histones, and the cell specific modifications to the histones is called the chromatin landscape. This affects which genes are exposed and which are hidden. So based upon the cell type, the genes are slated for activation by the transcription factor based upon how they are exposed in the chromatin structure. In addition to this, there is crosstalk between the various chromatin structures and the transcription factors, therefore many transcription factors are reused from cell to cell. Chromatin folding organizes these structures in the cell nucleus. The specific folding leads to interactions between genes that need to be expressed and elements that increase their expression. The more active portions of DNA are nearer the center of the nucleus, whereas the inactive sections are on the outside.

There are gene expression mechanisms to control how a gene is expressed. The specific folding of the DNA is the mechanism used to increase or decrease gene expression. There are also processes that make long lasting changes to the DNA itself such as DNA methylation. [1] DNA methylation is an epigenetic mechanism that occurs by the addition of a methyl (-CH3) group to DNA, thereby often modifying the function of the genes and affecting gene expression. The most widely characterized DNA methylation process is the covalent addition of the methyl group at the 5-carbon of the cytosine ring resulting in 5-methylcytosine (5-mC), also informally known as the “fifth base” of DNA. These methyl groups project into the major groove of DNA and inhibit transcription. In human DNA, 5-methylcytosine is found in approximately 1.5% of genomic DNA. DNA methylation can be transmitted from generation to generation, influences which genes are turned on or off in a specific cell type, and keeps us from over-expressing certain genes. The overexpression of genes can lead to conditions such as nervous disorders and cardiovascular disease. [1]

Note all of these things, the protein and DNA folding, transcription factors, chromatin landscape, and DNA methylation, are important regulatory steps in the human body for expressing certain genes in the right place and at the correct time. If any of these are perturbed (altered) there is the possibility of getting cancer among a variety of other problems. When we take all of these things into consideration, this is why it is so dangerous for one to take an mRNA vaccine, which is being pushed on the world’s population today! Nobody knows the future long term consequences of forcing the body to produce a protein that was never meant to be produced by the human body. The immediate side effects of the vaccine has led to the FDA and CDC imposing warnings on the vaccines which include blood clots, heart inflammation, neurological disease, and autoimmune disease. When we consider the cellular regulatory elements that we have just been discussing (very briefly), it is very clear why these immediate effects (health injuries) are taking place as the mRNA spike protein is interfering with the normal cellular mechanisms. The good news is that these regulatory elements we have been discussing back each other up, ie, you can have something go kind of wrong, and you’ll be OK as a cell, because these processes reinforce one another. The bad news is after having received the vaccine, many people are dying and having serious health related issues, some of which are mentioned above, and others include birth defects, miscarriages, and autoimmune disease, this is also why the CDC advises those who already have an autoimmune disease should not take the vaccine. All of these things are not even being mentioned by the media. This is why the CDC and FDA have placed warnings on the vaccines revealing the mRNA vaccine is overwhelming these cellular backup systems! Only time will tell the long term effects of the horrible decision many people are making today by taking the vaccine!

The Spiritual Insights that we receive from this type of research is related to something we read according to the Torah (specifically from Devarim / Deuteronomy 2:30). This research topic on DNA helps to draw out a spiritual insight that will help us to wisely understand what we have been and will be experiencing in this world at this specific time! We are living in perilous times; the world is drunk with its delusions and truth has fallen by the wayside. Untempered emotions are driven by stupefied thinking and all of these things are driven by a morbid and cowardly culture! Paul wrote that the last days would be exactly like this (see Timothy 3:1-5), Yeshua warned that apostasy would abound and the hearts of many would grow cold (Matthew 24:12), and that these days would be like the days of Noah, the days of great wickedness on this earth. (Matthew 24:37) The chaos of this present age (i.e. lockdowns, restrictions, mask wearing, etc), pride, liberal ideologies, forcing LGBTQ lifestyles on children, the programming of hollywood and the media the public willingly drinks in all of these things which work together to bring about the present situation we find ourselves in our world today! We need at this time to take even greater care in what we do, what we think, and in our relationship with God as the times are exactly what we read according to the Scriptures thus validating God’s Word! We note that Yeshua warned us twice to not be misled using the word πλανήσῃ· (planese, to lead astray, to deceive) according to Matthew 24:4-5.

ΚΑΤΑ ΜΑΤΘΑΙΟΝ 24:4-5
4 καὶ ἀποκριθεὶς ὁ Ἰησοῦς εἶπεν αὐτοῖς· Βλέπετε μή τις ὑμᾶς πλανήσῃ· 5 πολλοὶ γὰρ ἐλεύσονται ἐπὶ τῷ ὀνόματί μου λέγοντες· Ἐγώ εἰμι ὁ χριστός, καὶ πολλοὺς πλανήσουσιν. (SBL GNT)

Matthew 24:4-5
4 And Jesus answered and said to them, “See to it that no one misleads you. 5 For many will come in My name, saying, ‘I am the Christ,’ and they will mislead many people. (NASB)

He says that “many” will be deceived, this refers to a tremendous number of people. These things speak of a tremendous deception, and this deception is already in progress at this very moment. Those who do not know God are described as those who “walk in the futility (ματαιότητι) of their minds” (Ephesians 4:17 Τοῦτο οὖν λέγω καὶ μαρτύρομαι ἐν κυρίῳ, μηκέτι ὑμᾶς περιπατεῖν καθὼς καὶ τὰ ἔθνη περιπατεῖ ἐν ματαιότητι τοῦ νοὸς αὐτῶν). “They are darkened in their understanding, alienated from the life of God because of the ignorance (ἄγνοιαν) that is in them, due to their hardness of heart” (Ephesians 4:18 ἐσκοτωμένοι τῇ διανοίᾳ ὄντες, ἀπηλλοτριωμένοι τῆς ζωῆς τοῦ θεοῦ, διὰ τὴν ἄγνοιαν τὴν οὖσαν ἐν αὐτοῖς, διὰ τὴν πώρωσιν τῆς καρδίας αὐτῶν). We note that the hardness of heart is what led to the death of the firstborn in Egypt (see Shemot / Exodus 13:15). This is what the research topic on DNA is drawing out according to Devarim / Deuteronomy 2:30, the issue of the hardness or callousness of the heart.

ספר דברים פרק ב
וְלֹ֣א אָבָ֗ה סִיחֹן֙ מֶ֣לֶךְ חֶשְׁבּ֔וֹן הַעֲבִרֵ֖נוּ בּ֑וֹ כִּֽי־הִקְשָׁה֩ יְהוָ֨ה אֱלֹהֶ֜יךָ אֶת־רוּח֗וֹ וְאִמֵּץ֙ אֶת־לְבָב֔וֹ לְמַ֛עַן תִּתּ֥וֹ בְיָדְךָ֖ כַּיּ֥וֹם הַזֶּֽה׃

Devarim / Deuteronomy 2:30
30 But Sihon king of Heshbon was not willing for us to pass through his land; for the Lord your God hardened his spirit and made his heart obstinate, in order to hand him over to you, as he is today. (NASB)

Moshe tells us about Sihon King of Heshbon (סִיחֹן֙ מֶ֣לֶךְ חֶשְׁבּ֔וֹן) and says that Sihon לֹ֣א אָבָ֗ה “was unwilling” to allow Israel to pass (הַעֲבִרֵ֖נוּ) and the reason was כִּֽי־הִקְשָׁה֩ יְהוָ֨ה אֱלֹהֶ֜יךָ אֶת־רוּח֗וֹ “for the Lord your God Hardened his spirit.” So the Lord Hardened (הִקְשָׁה֩) his heart for the purpose of bringing about the destruction of him and his people. We remember this very same thing happened to Pharaoh who was stubborn to hear / listen refusing to heed the word of God and so God Hardened his heart such that he would not yield to the purposes and plans of God. The reason being so the Lord would bring His people out with a mighty hand! (Devarim / Deuteronomy 26:8) Note that the word הִקְשָׁה֩ is also used when describing the hardening of Pharaoh’s heart. (Shemot / Exodus 13:15, וַיְהִ֗י כִּֽי־הִקְשָׁ֣ה פַרְעֹה֮ לְשַׁלְּחֵנוּ֒ וַיַּהֲרֹ֨ג יְהֹוָ֤ה כָּל־בְּכוֹר֙ בְּאֶ֣רֶץ מִצְרַ֔יִם מִבְּכֹ֥ר אָדָ֖ם וְעַד־בְּכ֣וֹר בְּהֵמָ֑ה עַל־כֵּן֩ אֲנִ֨י זֹבֵ֜חַ לַֽיהוָ֗ה כָּל־פֶּ֤טֶר רֶ֙חֶם֙ הַזְּכָרִ֔ים וְכָל־בְּכ֥וֹר בָּנַ֖י אֶפְדֶּֽה׃) Notice what the Scriptures state, the hardness of heart leads to a state of callousness or apathy (ἀπηλγηκότες, literally meaning the “inability to feel”). This is the opposite of having empathy, compassion, or mercy towards others (Ephesians 4:19 οἵτινες ἀπηλγηκότες ἑαυτοὺς παρέδωκαν τῇ ἀσελγείᾳ εἰς ἐργασίαν ἀκαθαρσίας πάσης ἐν πλεονεξίᾳ.). This is the attitude that Pharaoh had, we are told according to the Torah. Considering the scientific research, there is so much evidence surrounding the issues of vaccine injury, and there is a system in place, in the media and government, that is working to hide the truth from the public such that people make the wrong decisions concerning the experimental vaccine. When the public is properly conditioned, groomed by the media, there is a hardening in part to the truth, a resistance to heeding the warnings that are all around us. This is the process the evil one has used for thousands of years to deceive men, women, and children throughout the world and the people of God, even at the time of the Torah! The Rabbinic Midrash draws out some interesting points about the problem of hardening the heart to truth.

Midrash Tanchuma Buber, Beshalach 1,Part 1
ויהי בשלח פרעה וגו’ (שמות יג יז). זש”ה חכם לבב ואמיץ כח מי הקשה אליו וישלם (איוב ט ד), [חכם לב], זה הקב”ה, שנאמר עמו חכמה (ותושיה) [וגבורה] וגו’ (שם יב יג), מי הקשה אליו וישלם, דור המבול נתקשו כנגדו ושטפן במים, דור הפלגה נתקשו כנגדו, הפיצם בכל העלם, אנשי סדום נתקשו כנגדו, מה היה סופן, וה’ המטיר על סדום (בראשית יט כד), פרעה אמר מי ה’ (שמות ה’ ב), והקב”ה אמר לו שלח את עמי (שם שם א), ואף הוא נתקשה, שנאמר ויהי כי הקשה פרעה (לשלחם) [לשלחנו] (שם יג טו), כיון שבאת מכת הבכורות עליו, מיד שלחן, לכך נאמר ויהי בשלח פרעה וגו’.
(Exod. 13:17:) NOW IT CAME TO PASS, WHEN PHARAOH HAD LET THE PEOPLE; GO…. This text is related (to Job 9:4): ONE WISE OF HEART AND MIGHTY IN STRENGTH—WHO HAS HARDENED HIMSELF AGAINST HIM AND PROSPERED? [ONE WISE OF HEART:] This is the Holy One, as stated (in Job 12:13): WITH HIM ARE WISDOM AND {UNDERSTANDING} [VALOR]. (Job 9:4, cont.:) WHO HAS HARDENED HIMSELF AGAINST HIM AND PROSPERED? The generation of the flood hardened themselves against him; so he washed them away with water. The generation of the dispersion hardened themselves against him; so, he dispersed them throughout the world. The people of Sodom hardened themselves against him, and what was their end? (Gen. 19:24:) THEN THE LORD RAINED DOWN UPON SODOM … BRIMSTONE AND FIRE. (Exod. 5:2:) PHARAOH SAID: WHO IS THE LORD? For the Holy One had said to him (in vs. 1): LET MY PEOPLE GO; but he also hardened himself, as stated (in Exod. 13:15): AND IT CAME TO PASS, WHEN PHARAOH HARDENED HIMSELF AGAINST LETTING {THEM} [US] GO. As soon as the plague of the first-born came upon him, he immediately let them go. It is therefore stated (in Exod. 13:17): NOW IT CAME TO PASS, WHEN PHARAOH HAD LET THE PEOPLE GO….

Notice how the question is asked “Who has hardened himself against Him (God) and prospered?” The examples given are to the generation of the flood, and they were destroyed, to the people of Sodom and they were rained upon by fire, to Pharaoh and Egypt and the Lord destroyed the children of those who refused to listen / heed the word of the Lord! Sin and rebellion brings about a state of callousness towards God and Truth. Sin alienates one from the ways of God and those who do not read their bibles do not understand, and so ignorance also produces a hardened heart, and likewise a hardened heart produces ignorance. We know how ignorance of God’s Word and His ways of righteousness, holiness, justice, and truth, leads to one having a darkened understanding, a futile mind, and allows deception to enter in! These things are historical facts as they are revealed to us in the pages of the Scriptures. This is because the inward man, the inner self, our hearts, determines what it is that we listen to, what it is that we acknowledge, and what it is that we ignore. Note also how Salvation in and of itself is a matter of believing in the truth of the testimony of the NT, the gospel message, believing from the heart (see Romans 10:9) and then living out that belief and faith! The mind is a gateway to all of who we are, and it is therefore imperative that we guard our way of thinking, and immerse ourselves in the truth of God’s Word. There is nothing wrong with questioning the narrative, regardless of what it is pertaining to. But when we do question the narrative, we must be grounded in our understanding, we must do due diligence to research the issues and understand the underlying science biologically, as in the case of the experimental vaccine. In matters of faith, we guard our minds immersing ourselves into God’s Word, in order to discern between good and evil. When one begins to tolerate sin, this leads to all sorts of problems as this world is ripe for judgment. Note that toleration is considered “collaboration” with the enemy! When one joins his or herself with wickedness as do those who mingle liberal ideologies with their faith, the mind is ripe / primed for deception! We note the Lord is clear on this point: “Woe to those who call evil good and good evil, and who turn darkness into light and light into darkness, to those who turn bitter into sweet and sweet into bitter. Woe to those who are wise in their own eyes, and shrewd in their own sight!” (Isaiah 5:20-21). We note the significance of the truth versus a lie; the truth sets people free, allows us to think for themselves, allows us to have freedoms and liberties and to show justice and mercy towards others, as opposed to lockdowns and being forced to stay home. This world and the evil one seeks to place us into bondage and enslave us to deception. We are instructed by God according to the Torah saying, “You are to distinguish between the holy and the common, and between the unclean and the clean.” (Vayikra / Leviticus 10:10, וּֽלֲהַבְדִּ֔יל בֵּ֥ין הַקֹּ֖דֶשׁ וּבֵ֣ין הַחֹ֑ל וּבֵ֥ין הַטָּמֵ֖א וּבֵ֥ין הַטָּהֽוֹר׃) Peter wrote that we are to be of a sober mind and alert as the evil one roams about like a roaring lion seeking whom he can devour. (1 Peter 5:8) Paul warns of this truth saying that in the last days deceitful spirits will increase. The idea is that demons will use people who have a seared conscience so as to deceive many. This is exactly what we are seeing taking place today, the great deception causing many people to make willful choices to place their bodies into chronic illness for the rest of their lives. Notice how all of these things work together to produce a world and culture exactly as Paul described according to 2 Timothy 3:1-5, “But realize this, that in the last days difficult times will come. For men will be lovers of self, lovers of money, boastful, arrogant, revilers, disobedient to parents, ungrateful, unholy, unloving, irreconcilable, malicious gossips, without self-control, brutal, haters of good, treacherous, reckless, conceited, lovers of pleasure rather than lovers of God, holding to a form of godliness, although they have denied its power; Avoid such men as these.” We note the number of vaccine injuries on the VAERS (Vaccine Adverse Event Reporting System) system is upwards of half a million people here in the USA alone and yet the government, businesses, private individuals, and the media are all continuing to promote the vaccine, this is exactly what we are reading about according to the Scriptures, how the days are evil and many will consider good evil and evil good. As time passes, people become more insensitive to sin, their consciences are seared and their hearts are hardened to the truth!

What the Scripture is teaching us is how there will be a deluding influence on the world in the last days so that many will believe what is false. Could this be any more clear than what we are seeing going on today? We have been warned from the very beginning of God’s Word, from the Torah, until the very last pages of the Scriptures in the book of Revelation, not to be deceived! Note that God allows evil and deception to increase so as to enact judgment on a God-rejecting world. The great increase in wickedness in this world, of lies and untruths are not just the work of sinful men, but is also the handiwork of the evil one. When asking the question of how each cell knows what portions of our DNA to use in protein production and cell function, we can learn a lot about our own biology simply by reading a few books on this topic. We also noted how all of these things, the protein and DNA folding, transcription factors, chromatin landscape, and DNA methylation, are important regulatory steps in the human body for expressing certain genes in the right place and at the correct time for proper cell function. If any of these are perturbed (altered) there is the possibility of getting cancer among a variety of other problems. When we consider the vaccine and the reasons behind why people are taking it, the motivation is one of fear and lack of trust in God! I have heard some quote Mark 16:18 they will pick up snakes with their hands; and when they drink deadly poison, it will not hurt them at all; they will place their hands on sick people, and they will get well (NASB) believing they will be fine. I do hope and pray this is true! However, this is analogous to sticking one’s hand into the snake’s mouth and asking God to protect them. The Scriptures reveal to us how it is the Lord God Almighty who is our healer and our source of life like what is written in Tehillim / Psalms 36:10, כִּי עִמְּךָ מְקוֹר חַיִּים בְּאוֹרְךָ נִרְאֶה אוֹר “For with You is the source of life; by Your light may we see light.” Our trust is in the Lord, the Scriptures speak of this over and over again. For those who have received the vaccine ignorantly, the only thing one can do is seek the mercy of God and the forgiveness of sins in the name of Yeshua the Messiah! I do believe even in our ignorance the Lord is able to save and heal us!

(Note, I did not say that it is a sin to take the vaccine so I dont want anybody claiming that is what I said!)

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Dr. Duane D. Miller received his Ph.D., M.S., and B.S. Degree in Chemical Engineering from The University of Akron Ohio. He is currently a Chemical Engineering Researcher. Duane’s research expertise has focused upon functional materials development for the control, conversion, and release of process gases in Energy production technologies. His R&D interests include computational chemistry, developing novel technologies for converting biomass to fuels and studying their fundamental interactions during the chemical conversion process. His past experience includes sorbent development for pre- and post-combustion CO2 and SO2 capture, selective absorption of H2S from methane streams, O2 capture for oxy-fuel combustion, photocatalytic reduction of alcohols, NOx reduction catalysis, the development of oxygen carriers to combust fossil fuels (CH4 and coal) for the chemical looping combustion processes, and the extraction of rare earth elements using patent pending sorbents. His research expertise has focused on operando-characterization using Infrared, Raman, and UV-Vis spectroscopy to observe the nature of the catalytic active sites and reaction intermediates under realistic reaction conditions, allowing direct correlation of molecular/electronic structures with catalyst performance during Gas-Solid / Liquid-Solid Adsorption and Photocatalytic Processes with real time online analysis of reaction products using ICP-MS and mass spectrometry. His current work involves a multi-disciplinary approach to developing, understanding, and improving the catalytic gasification of coal and methane, high temperature chemical looping combustion, and the catalytic decomposition and gasification of biomass and coal using novel microwave reactor.​ He has been studying the Hebrew Scriptures and the Torah for 20+ years and sharing what he has learned. The studies developed for MATSATI.COM are freely to be used by everyone, to God be the Glory!